By Peter E. Voytek (auth.), Vicki L. Dellarco, Peter E. Voytek, Alexander Hollaender, B. R. Brinkley, Ernest B. Hook, Montrose J. Moses, Frederick J. de Serres, T. C. Hsu, Liane B. Russell, Raymond R. Tice, Michael D. Waters (eds.)
The "Symposium on Aneuploidy: Etiology and Mechanisms" was once held on the Carnegie establishment of Washington Auditorium from March 25-29. 1985. This Symposium constructed as a result of the worry of the Environmen tal defense enterprise with the aid of the nationwide Institute of Envi ronmental health and wellbeing Sciences approximately human publicity to environmental brokers that reason aneuploidy. this system used to be selected to discover what's presently recognized concerning the underlying reasons, the origins, and the level of the prob lem of human aneuploidy, and no matter if publicity to environmental brokers is assodated with an elevated occurrence of aneuploidy in people. easy learn findings within the sector of mitosis and meiosis have been provided and relating to attainable mechanisms of the way aneuploidy will be produced spontane ously and chemically. A survey of information in regards to the chemical induction of aneuploidy in experimental organisms used to be awarded. remarkable scientists from various fields have been invited to hide a extensive viewpoint of aneu ploidy from the molecular points to the human scenario. we are hoping that the book of the complaints will proportion the enthu siasm of the assembly and its clinical content material. the subject of aneuploidy has obtained little realization and it's the goal of this quantity to set up a systematic foundation for assessing future health hazards posed via environ psychological exposures to aneuploidy-inducing chemical substances. Vicki L. DeJlarco Peter E. Voytek Alexander Hollaender vii ACKNOWLEDGEMENT The Editors of the complaints of the "Symposium on Aneuploidy" desire to recognize the help of Dr. Elizabeth L.
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Extra info for Aneuploidy: Etiology and Mechanisms
2b. All rates are sex-specific. 7/1,000 3/1,000 3x 4x 35x 4/1,000 4/1,000 none observed 4/1,OOOb 4x 4x Oc 4xb 20/1,000 10/1,000 2/1,000 4/1,OOOb 20x lOx Frequency in exclusively mental settings Increased risk Frequency in exclusively penal settings Increased risk Frequency in mentalpenal settings Increased risk XXYY xxx Table 100x (including mosaics) 3x 4xb : No higher probably than 1/30,000. c Estimate based on sparse data. Upper 95% confidence limit is around 16-fold. 2% of 318 couples with abnormalities, but noted that in only a small proportion had other causes of repeated abortion been ruled out prior to cytogenetic investigation.
2%) well-known sign of Turner syndrome (45,X). But in females (under age 15 yr) with short stature only (height ~ 3rd percentile for age), there was a high rate of cytogenetic abnormality (35%), including 8/57 cases with a nonmosaic 45,X pattern. This is a surprisingly high proportion. ) were presumably screened into another group, but it is possible that there was additional phenotypic selection that was not recognized over and above short stature in the group of small girls. It will be interesting to see what subsequent studies of this type reveal.
Economists invariably begin studies in areas such as aneuploidy by asking basic questions about data that are needed to prepare their estimates, such as: How often does aneuploidy occur? What are the costs of different methods ot preventing a case from arising? What is the likelihood that a person with aneuploidy will be gainfully employed? What are the costs of caring for persons with aneuploidy? The answers that are given to these questions are usually subject to wide error, which in turn sets the limits as to the accuracy and reliability of subsequent estimates of the social cost of aneuploidy or to the costs and benefits of treatment.